News Summary
No. 13 Ole Miss faces No. 4 LSU in a pivotal SEC clash with playoff implications. Ole Miss looks to avenge a narrow overtime loss from last season as both teams aim for a strong conference standing. The matchup is marked by Ole Miss’s explosive offense against LSU’s formidable defense. As they prepare for the game, the stakes are high as both teams vie for a spot in the College Football Playoff.
Oxford, Mississippi – No. 13 Ole Miss (4-0, 2-0 SEC) will host No. 4 LSU (4-0, 1-0 SEC) on September 27, 2025, in what is anticipated to be a crucial Southeastern Conference showdown with significant College Football Playoff implications. The game is scheduled to kick off at 2:30 p.m. CT at Vaught-Hemingway Stadium.
The matchup carries substantial weight for both teams in the SEC standings, as they aim to enhance their playoff hopes. Ole Miss is currently a slight favorite, with a 1.5-point edge over LSU according to BetMGM. This encounter promises to test both teams, particularly Ole Miss, which looks to avenge a narrow defeat to the Tigers last season, where they fell 29-26 in overtime.
This will be the 114th all-time meeting between Ole Miss and LSU, cementing LSU as Ole Miss’s second most-played opponent, following Mississippi State. Historical records show that Ole Miss has achieved only three all-time victories against a top-five LSU team, with the last triumph dating back to 1965.
Ole Miss has started the season strong, marking their second consecutive season with a 4-0 start, a feat not accomplished since 2014 and 2015. They lead the Football Bowl Subdivision (FBS) with 21 plays of 30 yards or more and are tied for the lead with 32 plays of 20 yards or more through the first four games.
Trinidad Chambliss is expected to take the helm as quarterback for Ole Miss due to the ongoing recovery of Austin Simmons from injury. While Coach Lane Kiffin has indicated that Simmons will resume his starting role once healthy, the timeline for his return remains uncertain. In contrast, LSU’s Garrett Nussmeier has been performing well, completing nearly 69% of his passes and averaging 241 passing yards per game.
On the ground, Ole Miss running back Kewan Lacy has made an impressive start to the season, recording over 100 rushing yards in consecutive games. Despite their offensive success, Ole Miss faces challenges defensively, ranking poorly in red zone defense and rush success rate allowed. In their latest game, the Rebels secured a dominant 45-10 victory over Tulane, maintaining an average of 544 yards and 44.8 points per game throughout the current season.
LSU, meanwhile, boasts one of the best scoring defenses in the SEC, having allowed only 37 points over their first four games, which averages out to just 9.25 points per game. This defensive strength will be put to the test against the high-scoring Ole Miss offense, known for its chaos-inducing style, conflicting with LSU’s more methodical approach to gameplay.
The significance of this matchup cannot be understated, as both teams are in contention for the SEC title and vying for a spot in the College Football Playoff series. Fans and analysts alike are poised for a thrilling clash that could reshape the landscape of the conference and have lasting repercussions for both programs heading into the remainder of the season.
As the game approaches, both teams will finalize their rosters, with LSU laboring over the availability of starting running back Caden Durham, adding an extra layer of intrigue to this essential SEC battle.
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Additional Resources
- ESPN Betting: LSU Tigers vs. Ole Miss Rebels
- Clarion Ledger: Ole Miss vs. LSU Predictions
- Knox News: SEC College Football Games Live
- College Football News: LSU vs. Ole Miss Prediction
- SI.com: ESPN Computer Model Prediction
- Wikipedia: Ole Miss Rebels Football
- Google Search: LSU Football
- Google Scholar: SEC College Football
- Encyclopedia Britannica: Football
- Google News: Ole Miss vs. LSU
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